Invention Grant
US08193323B1 mpl ligand (thrombopoietin), active fragments thereof, and fusion proteins and compositions comprising mpl ligand and other cytokines
失效
mpl配体（血小板生成素），其活性片段和融合蛋白以及包含mpl配体和其它细胞因子的组合物
- Patent Title: mpl ligand (thrombopoietin), active fragments thereof, and fusion proteins and compositions comprising mpl ligand and other cytokines
- Patent Title (中): mpl配体（血小板生成素），其活性片段和融合蛋白以及包含mpl配体和其它细胞因子的组合物
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Application No.: US08423194Application Date: 1995-04-18
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Publication No.: US08193323B1Publication Date: 2012-06-05
- Inventor: Dan L. Eaton , Frederic J. De Sauvage
- Applicant: Dan L. Eaton , Frederic J. De Sauvage
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Merchant & Gould P.C.
- Main IPC: C07K14/52
- IPC: C07K14/52 ; C07K14/54 ; A61K38/19 ; A61K38/18 ; A61K38/20
Abstract:
Isolated mpl ligand, isolated DNA encoding mpl ligand, and recombinant or synthetic methods of preparing mpl ligand are disclosed. These mpl ligands are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocytes and megakaryocyte progenitor cells. Accordingly, these compounds may be used for treatment of thrombocytopenia.
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