Invention Grant
US08193246B2 Lipids and lipid assemblies comprising transfection enhancer elements
有权
包含转染增强子元件的脂质和脂质组件
- Patent Title: Lipids and lipid assemblies comprising transfection enhancer elements
- Patent Title (中): 包含转染增强子元件的脂质和脂质组件
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Application No.: US12004154Application Date: 2007-12-19
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Publication No.: US08193246B2Publication Date: 2012-06-05
- Inventor: Steffen Panzner , Evgenios Siepi , Silke Lutz , Christian Reinsch , Claudia Müller
- Applicant: Steffen Panzner , Evgenios Siepi , Silke Lutz , Christian Reinsch , Claudia Müller
- Applicant Address: US WA Bothell
- Assignee: Marina Biotech, Inc.
- Current Assignee: Marina Biotech, Inc.
- Current Assignee Address: US WA Bothell
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent Ivor R. Elrifi
- Priority: EP06256450 20061219; EP07117189 20070925
- Main IPC: A61K31/20
- IPC: A61K31/20 ; C07C53/122 ; C07C231/00
Abstract:
Lipid assemblies, such as liposomes, comprising transfection enhancer elements (TEE's), which are complexed with the lipid assemblies by means of ionic interactions, or lipids incorporating such TEE's are disclosed for enhancing the fusogenicity of the lipid assemblies. The TEE's have the formula: hydrophobic moiety-pH sensitive hydrophilic moiety (II) The pH sensitive hydrophilic moiety of each TEE is a weak acid having a pka of between 2 and 6 or a zwitterionic structure comprising a combination of acidic groups with weak bases having a pKa of between 3 and 8. Lipids incorporating one or more such TEEs have the formula (I): Lipid moiety-[Hydrophobic moiety-pH sensitive hydrophilic moiety] (I).
Public/Granted literature
- US20080306153A1 Lipids and lipid assemblies comprising transfection enhancer elements Public/Granted day:2008-12-11
Information query
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