Invention Grant
US08193225B2 Isoxazole amides, derivatives and methods of chemical induction of neurogenesis
有权
异恶唑酰胺，衍生物和化学诱导神经发生的方法
- Patent Title: Isoxazole amides, derivatives and methods of chemical induction of neurogenesis
- Patent Title (中): 异恶唑酰胺，衍生物和化学诱导神经发生的方法
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Application No.: US11974479Application Date: 2007-10-12
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Publication No.: US08193225B2Publication Date: 2012-06-05
- Inventor: Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
- Applicant: Jay Schneider , Jenny Hsieh , Douglas Frantz , Steven L. McKnight , Joseph M. Ready
- Applicant Address: US TX Austin
- Assignee: The Board of Regents of the University of Texas System
- Current Assignee: The Board of Regents of the University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Fulbright & Jaworski
- Main IPC: A61K31/422
- IPC: A61K31/422 ; C07D261/18
Abstract:
The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The compounds are isoxazole amides and derivatives thereof. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.
Public/Granted literature
- US20090036451A1 Chemical inducers of neurogenesis Public/Granted day:2009-02-05
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