Invention Grant
US08193171B2 13,13-dimethyl-des-C,D analogs of 1α,25-dihydroxy-19-nor-vitamin D3 compounds and topical composition dosage forms and methods of treating skin conditions thereof
有权
1α，25-二羟基-19-去甲维生素D3化合物的13,13-二甲基-de-C，D类似物和局部组合物剂型及治疗其皮肤病症的方法
- Patent Title: 13,13-dimethyl-des-C,D analogs of 1α,25-dihydroxy-19-nor-vitamin D3 compounds and topical composition dosage forms and methods of treating skin conditions thereof
- Patent Title (中): 1α，25-二羟基-19-去甲维生素D3化合物的13,13-二甲基-de-C，D类似物和局部组合物剂型及治疗其皮肤病症的方法
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Application No.: US12357702Application Date: 2009-01-22
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Publication No.: US08193171B2Publication Date: 2012-06-05
- Inventor: Hector F. DeLuca , Margaret Clagett-Dame , Lori A. Plum , Rafal R. Sicinski , Katarzyna Plonska-Ocypa , Nirca J. Nieves , Pawel Grzywacz
- Applicant: Hector F. DeLuca , Margaret Clagett-Dame , Lori A. Plum , Rafal R. Sicinski , Katarzyna Plonska-Ocypa , Nirca J. Nieves , Pawel Grzywacz
- Applicant Address: US WI Madison
- Assignee: Wisconsin Alumni Research Foundation
- Current Assignee: Wisconsin Alumni Research Foundation
- Current Assignee Address: US WI Madison
- Agency: Foley & Lardner LLP
- Agent Joseph P. Meara
- Main IPC: A61K31/047
- IPC: A61K31/047 ; C07C35/17 ; C07C401/00 ; A61P17/00
Abstract:
13,13-Dimethyl-des-C,D analogs of 1α,25-dihydroxy-19-nor-vitamin D3 compounds and topical composition dosage forms thereof, and methods of treating skin conditions thereof. Exemplary active pharmaceutical ingredients include (1R,3R)-5-[(E)-(S)-11′-hydroxy-5′,5′,7′,11′-tetramethyl-dodec-2′-enylidene]-2-methylene-cyclohexane-1,3-diol, (1R,3R)-5-[(Z)-(S)-11′-hydroxy-5′,5′,7′,11′-tetramethyl-dodec-2′-enylidene]-2-methylene-cyclohexane-1,3-diol, (1R,3R)-5-[(E)-(R)-11′-hydroxy-5′,5′,7′,11′-tetramethyl-dodec-2′-enylidene]-2-methylene-cyclohexane-1,3-diol, and (1R,3R)-5-[(Z)-(R)-11′-hydroxy-5′,5′,7′,11′-tetramethyl-dodec-2′-enylidene]-2-methylene-cyclohexane-1,3-diol.
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