Invention Grant
US08192986B2 Compositions and methods for treatment of protein misfolding diseases
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用于治疗蛋白质错折叠疾病的组合物和方法
- Patent Title: Compositions and methods for treatment of protein misfolding diseases
- Patent Title (中): 用于治疗蛋白质错折叠疾病的组合物和方法
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Application No.: US11568653Application Date: 2005-05-04
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Publication No.: US08192986B2Publication Date: 2012-06-05
- Inventor: Susan L. Lindquist , Martin Duennwald
- Applicant: Susan L. Lindquist , Martin Duennwald
- Applicant Address: US MA Cambridge
- Assignee: Whitehead Institute for Biomedical Research
- Current Assignee: Whitehead Institute for Biomedical Research
- Current Assignee Address: US MA Cambridge
- Agency: Fish & Richardson P.C.
- International Application: PCT/US2005/015692 WO 20050504
- International Announcement: WO2005/108599 WO 20051117
- Main IPC: C12Q1/00
- IPC: C12Q1/00 ; C12Q1/02 ; G01N33/53
Abstract:
Disclosed are methods for identifying compounds that modulate huntingtin mediated impairment of protein degradation pathways. Compounds identified by such screens can be used as candidate drugs for the treatment of prevention of polyglutamine diseases such as Huntington's Disease.
Public/Granted literature
- US20080045607A1 Compositions and Methods for Treatment of Protein Misfolding Diseases Public/Granted day:2008-02-21
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