Invention Grant
- Patent Title: Detection of mutations in a gene associated with resistance to viral infection, OAS1
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Application No.: US11592711Application Date: 2006-11-02
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Publication No.: US08192973B2Publication Date: 2012-06-05
- Inventor: Shawn P Iadonato , Charles L Magness , Gary Rosenberg , Christina A Scherer , Thierry Guillaudeux
- Applicant: Shawn P Iadonato , Charles L Magness , Gary Rosenberg , Christina A Scherer , Thierry Guillaudeux
- Applicant Address: US WA Seattle
- Assignee: Kineta Two, LLC
- Current Assignee: Kineta Two, LLC
- Current Assignee Address: US WA Seattle
- Agency: K&L Gates LLP
- Agent C. Rachal Winger
- Main IPC: C12N9/12
- IPC: C12N9/12
Abstract:
A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided.
Public/Granted literature
- US20110071073A1 Detection of mutations in a gene associated with resistance to viral infection, OAS1 Public/Granted day:2011-03-24
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