Invention Grant
US08192942B2 Affinity separation by partition enhancing material conjugated biomolecules in aqueous two-phase extraction system
有权
通过分层增强材料共轭生物分子在水相两相萃取系统中的亲和力分离
- Patent Title: Affinity separation by partition enhancing material conjugated biomolecules in aqueous two-phase extraction system
- Patent Title (中): 通过分层增强材料共轭生物分子在水相两相萃取系统中的亲和力分离
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Application No.: US12303364Application Date: 2008-01-21
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Publication No.: US08192942B2Publication Date: 2012-06-05
- Inventor: Yoon-Mo Koo , Woo-Jin Chang , Hye-Mee Park
- Applicant: Yoon-Mo Koo , Woo-Jin Chang , Hye-Mee Park
- Applicant Address: KR Incheon
- Assignee: INHA-Industry Partnership Institute
- Current Assignee: INHA-Industry Partnership Institute
- Current Assignee Address: KR Incheon
- Agency: Lucas & Mercanti, LLP
- Priority: KR10-2007-0006001 20070119
- International Application: PCT/KR2008/000356 WO 20080121
- International Announcement: WO2008/088200 WO 20080724
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/535 ; G01N33/536 ; C12Q1/28
Abstract:
The present invention relates to a method for separating a material that has affinity to an antibody by using a protein-antibody conjugate with modified partition characteristics, more precisely a method for affinity separation to separate a material specifically binds to an antibody, in which an antibody is conjugated to a protein to modify partition characteristics of the protein-antibody conjugate. The method of the present invention can be effectively and widely used as a safe and efficient separation method for biomolecules since it takes advantages of safe aqueous two-phase extraction system and high selective molecular specific conjugation.
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