A system, method and computer program product for managing a plurality of applications in a computer cluster. Each application is able to run on a particular node in the cluster. In one embodiment, associations are maintained among a plurality of modes and the plurality of applications, with each application being associated with at least one mode. Responsive to designation of at least one mode as active for the cluster, each application that is associated with an active mode is flagged as eligible for activation, each inactive application that is not associated with any active mode is flagged as ineligible for activation, and each active application that is not associated with any active mode is flagged as ineligible for activation and inactivated. Flagging as eligible, flagging as ineligible and flagging as ineligible and inactivating may be performed in any order, and inactivating is sequenced according to dependencies among the applications.