A smart endpoint and a smart monitoring system having the smart endpoint are provided. The smart endpoint includes a central processing unit (CPU), an interface module, a digital signal processing unit, and a memory module. The interface module is coupled to the CPU for receiving a plurality of heterogeneous monitoring signals and an identification code. The digital signal processing unit is coupled to the CPU for integrally considering the monitoring signals and the identification code to determine an abnormal event, and generate an abnormal event data thereby. The memory module is coupled to the CPU for recording the abnormal event data. As such, the present invention is adapted to determine an occurrence of an abnormal event, by which the passive monitoring can be upgraded to an active monitoring and analyzing, and thus achieving a smart monitoring.