A system and method are provided for reclaiming an enriched radioisotope starting material (14) from a target body (12). The system and method enable reclaiming the starting material in a relatively short time (e.g., several hours) after the target body's bombardment with energetic particles, greatly simplifying the target body's chemical processing, as well as reducing the cost of such processing (e.g., reducing the need for costly long-term storage). Specifically, a chemical protective layer (16) is disposed between a radioisotope starting material (14) and a base material (18) of the target body (12). After the target body is irradiated with a suitable source (e.g., particle accelerator), then the irradiated radioisotope starting material and be removed without removing the base material due to the protection provided by the chemical protective layer. The system and method also enable the operator to obtain three different radioisotopes in a single bombardment of the target body, further reducing cost of radioisotope production.