A system and related methods for dynamically re-configuring a radio frequency identification tag reader, engaging software business processes, or combinations of both, using a radio-frequency-readable configuration tag which physically associated with one or more RFID-tagged articles in a physical handling flow. The configuration tag reader is positioned prior to a radio frequency identification tag reader in said material handling flow, which allows the configuration reader to read the contents of the configuration tags before the articles reach the identification tag reader. Based on the contents of the read configuration tags, one or more selected business processes are initiated to customize the handling process of the tagged items.