Invention Grant
US08168854B2 Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression
有权
通过靶向TCL1表达在小鼠中建模的人慢性淋巴细胞白血病
- Patent Title: Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression
- Patent Title (中): 通过靶向TCL1表达在小鼠中建模的人慢性淋巴细胞白血病
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Application No.: US12758177Application Date: 2010-04-12
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Publication No.: US08168854B2Publication Date: 2012-05-01
- Inventor: Carlo M. Croce
- Applicant: Carlo M. Croce
- Applicant Address: US PA Philadelphia
- Assignee: Thomas Jefferson University
- Current Assignee: Thomas Jefferson University
- Current Assignee Address: US PA Philadelphia
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- Main IPC: G01N33/48
- IPC: G01N33/48 ; G01N33/50 ; G01N33/483 ; A01K67/027
Abstract:
Transgenic animals containing a nucleic acid sequence encoding TCL1 operably linked to transcriptional control sequences directing expression to B cells are described. Such transgenic animals provide a useful animal model system for human B cell chronic lymphocytic leukemia.
Public/Granted literature
- US20100192235A1 HUMAN CHRONIC LYMPHOCYTIC LEUKEMIA MODELED IN MOUSE BY TARGETED TCL1 EXPRESSION Public/Granted day:2010-07-29
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