Invention Grant
- Patent Title: Caspase inhibitor prodrugs
- Patent Title (中): 胱天蛋白酶抑制剂前药
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Application No.: US12971649Application Date: 2010-12-17
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Publication No.: US08168798B2Publication Date: 2012-05-01
- Inventor: Steven Durrant , Jean-Damien Charrier , John Studley
- Applicant: Steven Durrant , Jean-Damien Charrier , John Studley
- Applicant Address: US MA Cambridge
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Cambridge
- Agent Jennifer G. Che
- Main IPC: C07D498/14
- IPC: C07D498/14
Abstract:
This invention relates to prodrugs of caspase inhibitors comprising of a furo[3,2-d]oxazolin-5-one moiety which, under specific conditions, can convert into biologically active compounds, particularly caspase inhibitors.This invention also relates to the processes for preparing these prodrugs of caspase inhibitors.This invention further relates to pharmaceutical compositions comprising said prodrugs and to the use thereof for the treatment of diseases related to inflammatory or degenerative conditions.
Public/Granted literature
- US20110137037A1 CASPASE INHIBITOR PRODRUGS Public/Granted day:2011-06-09
Information query
