Invention Grant
US08168771B2 Use of consensus sequence as vaccine antigen to enhance recognition of virulent viral variants
有权
使用共有序列作为疫苗抗原来增强对毒性病毒变体的识别
- Patent Title: Use of consensus sequence as vaccine antigen to enhance recognition of virulent viral variants
- Patent Title (中): 使用共有序列作为疫苗抗原来增强对毒性病毒变体的识别
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Application No.: US11815203Application Date: 2006-01-31
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Publication No.: US08168771B2Publication Date: 2012-05-01
- Inventor: Stuart C. Ray , Andrew L. Cox , David L. Thomas
- Applicant: Stuart C. Ray , Andrew L. Cox , David L. Thomas
- Applicant Address: US MD Baltimore
- Assignee: The Johns Hopkins University
- Current Assignee: The Johns Hopkins University
- Current Assignee Address: US MD Baltimore
- Agency: Banner & Witcoff, Ltd
- International Application: PCT/US2006/003514 WO 20060131
- International Announcement: WO2006/086188 WO 20060817
- Main IPC: C07H21/00
- IPC: C07H21/00 ; A61K39/29
Abstract:
The invention provides consensus sequences for hepatitis C virus 1a and 1b. Also provided are non-synonymous changes for each residue of the consensus sequences. These sequences are useful as compositions or vaccines for prophylactic use or treating HCV-infected individuals. Also provided are methods for lessening the chances for a HCV-infected individual to enter a chronic phase of infection and methods of diagnosing an individual with HCV 1a or HCV 1b infection.
Public/Granted literature
- US20090186045A1 USE OF CONSENSUS SEQUENCE AS VACCINE ANTIGEN TO ENHANCE RECOGNITION OF VIRULENT VIRAL VARIANTS Public/Granted day:2009-07-23
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