Invention Grant
- Patent Title: Aminodihydrothiazine derivatives substituted with a cyclic group
- Patent Title (中): 用环状基团取代的氨基二氢噻嗪衍生物
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Application No.: US12596796Application Date: 2008-04-23
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Publication No.: US08168630B2Publication Date: 2012-05-01
- Inventor: Yuusuke Tamura , Shinji Suzuki , Yukio Tada , Shuji Yonezawa , Chiaki Fujikoshi , Sae Matsumoto , Yuuji Kooriyama , Tatsuhiko Ueno
- Applicant: Yuusuke Tamura , Shinji Suzuki , Yukio Tada , Shuji Yonezawa , Chiaki Fujikoshi , Sae Matsumoto , Yuuji Kooriyama , Tatsuhiko Ueno
- Applicant Address: JP Osaka
- Assignee: Shionogi & Co., Ltd.
- Current Assignee: Shionogi & Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Hamre, Schumann, Mueller & Larson, P.C.
- Priority: JP2007-114288 20070424; JP2007-290589 20071108
- International Application: PCT/JP2008/057847 WO 20080423
- International Announcement: WO2008/133274 WO 20081106
- Main IPC: C07D417/12
- IPC: C07D417/12 ; C07D417/14 ; A61K31/497 ; A61K31/54

Abstract:
This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R3a, R3b, R3c and R3d are each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.; a pharmaceutically acceptable salt or solvate thereof, which is useful for treating diseases induced by production, secretion and/or deposition of amyloid β protein.
Public/Granted literature
- US20100075957A1 AMINODIHYDROTHIAZINE DERIVATIVES SUBSTITUTED WITH A CYCLIC GROUP Public/Granted day:2010-03-25
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