Invention Grant
US08168610B2 Bispecific oligonucleotide for the treatment of CNS malignancies
有权
用于治疗CNS恶性肿瘤的双特异性寡核苷酸
- Patent Title: Bispecific oligonucleotide for the treatment of CNS malignancies
- Patent Title (中): 用于治疗CNS恶性肿瘤的双特异性寡核苷酸
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Application No.: US13004421Application Date: 2011-01-11
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Publication No.: US08168610B2Publication Date: 2012-05-01
- Inventor: Martin Gleave , Michael N. Pollak , Randy J. Leavitt
- Applicant: Martin Gleave , Michael N. Pollak , Randy J. Leavitt
- Applicant Address: CA Vancouver
- Assignee: The University of British Columbia
- Current Assignee: The University of British Columbia
- Current Assignee Address: CA Vancouver
- Agency: Larson & Anderson, LLC.
- Main IPC: A01N43/04
- IPC: A01N43/04 ; A61K31/70 ; C07H21/04 ; C12Q1/68 ; C12N5/00
Abstract:
CNS malignancy is treated in a subject suffering from a CNS malignancy by administering to the subject an antisense oligonucleotide having a sequence of bases that is complementary to portions of both the gene encoding IGFBP-2 and the gene encoding IGFBP-5, and which is of sufficient length to act as an inhibitor of the effective amount of IGFBP-2 and IGFBP-5, in an amount effective to reduce effective levels of IGFBP-2 and IGFBP-5 in cells of the CNS malignancy.
Public/Granted literature
- US20110152354A1 Bispecific Oligonucleotide for the Treatment of CNS Malignancies Public/Granted day:2011-06-23
Information query
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