Invention Grant
US08168404B2 Methods to treat cancer with 10-propargyl-10-deazaaminopterin and methods for assessing cancer for increased sensitivity to 10-propargyl-10-deazaaminopterin
有权
用10-炔丙基-10脱甲氨蝶呤治疗癌症的方法和用于评估癌症以增加对10-炔丙基-10-脱氮基蝶呤的敏感性的方法
- Patent Title: Methods to treat cancer with 10-propargyl-10-deazaaminopterin and methods for assessing cancer for increased sensitivity to 10-propargyl-10-deazaaminopterin
- Patent Title (中): 用10-炔丙基-10脱甲氨蝶呤治疗癌症的方法和用于评估癌症以增加对10-炔丙基-10-脱氮基蝶呤的敏感性的方法
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Application No.: US12637254Application Date: 2009-12-14
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Publication No.: US08168404B2Publication Date: 2012-05-01
- Inventor: Owen A. O'Connor , Francis M. Sirotnak
- Applicant: Owen A. O'Connor , Francis M. Sirotnak
- Applicant Address: US NY New York
- Assignee: Sloan-Kettering Institute for Cancer Research
- Current Assignee: Sloan-Kettering Institute for Cancer Research
- Current Assignee Address: US NY New York
- Agency: Larson & Anderson, LLC
- Main IPC: G01N33/574
- IPC: G01N33/574
Abstract:
The present invention relates to a method for assessing the sensitivity of a patient's cancer to treatment with 10-propargyl-10-deazaminopterin and a method for selecting a patient for treatment of cancer with 10-propargyl-10-deazaminopterin, by determining the amount of a selected polypeptide expressed by the cancer and comparing the amount with the amount of the selected polypeptide expressed by a reference cancer, wherein the polypeptide includes a member of folate pathways within cells and may include at least one of reduced folate carrier-1 enzyme (RFC-1), dihydrofolate reductase (DHFR), folylpoly-gamma-glutamate synthetase (FPGS), thymidylate synthase (TS), γ-glutamyl hydrolase (GGH), and glycinamide ribonucleotide formyltransferase (GARFT). The present invention also relates to the use of 10-propargyl-10-deazaminopterin in the treatment of multiple myeloma.
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