Invention Grant
US08168208B1 Silica-calcium phosphate bioactive composite for improved synthetic graft resorbability and tissue regeneration 有权
二氧化硅 - 磷酸钙生物活性复合材料用于改善合成移植物再吸收和组织再生

Silica-calcium phosphate bioactive composite for improved synthetic graft resorbability and tissue regeneration
Abstract:
A method is disclosed for the generation of bone tissue by the preparation and the application to bone defect sites of a resorbable silica-calcium phosphate bioactive composite (SCPC) that finds utility as a bone tissue engineering scaffold. The resorbable silica-calcium phosphate bioactive composite can be applied directly to bone defect or can be employed as a bioactive coating on implants to facilitate bone growth around the implant. The resorbable silica-calcium phosphate bioactive composite is prepared from a mixture of a silica salt in an amount to provide between about 0.31 moles and about 0.93 moles of silica and calcium phosphate, said silica salt being present in the resorbable silica-calcium phosphate bioactive composite. The mixture is thermally treated at a temperature ranging between about 130° C. to about 1200° C. to form said resorbable silica-calcium phosphate bioactive composite having a phase composition comprising a thermally treated form of silica and calcium phosphate.
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