Invention Grant
US08168168B2 Infectivity-enhanced conditionally-replicative adenovirus and uses thereof
有权
感染性增强的条件复制型腺病毒及其用途
- Patent Title: Infectivity-enhanced conditionally-replicative adenovirus and uses thereof
- Patent Title (中): 感染性增强的条件复制型腺病毒及其用途
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Application No.: US12636134Application Date: 2009-12-11
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Publication No.: US08168168B2Publication Date: 2012-05-01
- Inventor: Juan Fueyo , Candelaria Gomez-Manzano
- Applicant: Juan Fueyo , Candelaria Gomez-Manzano
- Main IPC: C12N15/09
- IPC: C12N15/09 ; C12N15/34 ; C12N7/00
Abstract:
A modified adenovirus capable of overcoming the problem of low level of coxsackie-adenovirus receptor (CAR) expression on tumor cells and methods of using such adenovirus are provided. The fiber protein of the adenovirus is modified by insertion or replacement so as to target the adenovirus to tumor cells, and the replication of the modified adenovirus is limited to tumor cells due to specific promoter control or mutations in E1a or E1b genes.
Public/Granted literature
- US20110045583A1 INFECTIVITY-ENHANCED CONDITIONALLY-REPLICATIVE ADENOVIRUS AND USES THEREOF Public/Granted day:2011-02-24
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