A full body twisting exercise machine has a support frame comprising a lower layer portion and an upper layer portion, a bearing respectively installed at the lower and the upper layer portions, a revolving shaft disposed though both bearings, one end of the revolving shaft protruding from the upper layer portion and connected to a crank and having an extension bar, a free end of the extension bar having a connecting portion; a connecting rod, a driving rod and a handle, an aperture of the connecting rod pivoted to the connecting portion of the extension bar and secured to one end of the driving rod; another end of the driving rod connected to a handle; and a flywheel disposed between the lower layer portion and the upper layer portion and jacketing the revolving shaft, and the lower layer portion of the support frame having a damping device.