A blow molding machine with air conditioning that while minimizing the introduction rate of outside air maintains constant temperature in a plant building and the interior of a blow molding machine and production of a bottle as a final configuration with stability in its measurement value. The machine is constructed so that air for biaxially stretching blow molding together with hot air of heating zone and internal air of a plant building is suctioned by suction chamber, filtered by primary filter and secondary filter into clean air, brought into heat exchange with primary cooling coil, fed under pressure by air blower and released through low-temperature duct into the interior of the plant building. Further, a housing on its side face is provided with vent to allow reflux of the clean air released into the interior of the plant building and flow into the heating zone and blow zone.