The present invention provides an improved shoe sole for a running shoe conducive to a midfoot striking gait including a cushioning element positioned between the upper surface and the ground-contacting surface, at least a portion of which is positioned on a lateral side of the sole and contained within a region between 15% and 90% of the length of the shoe sole as measured from a rearfoot end of the sole. One or more high abrasion-resistant ground-contacting crash pads are positioned below the cushioning element, and include a lateral side portion contained within a region extending a distance of 20% the length of the shoe sole, as measured from a rearfoot end of the shoe sole. The shoe sole, preferably devoid of at least vertical arch sculpting, also includes a longitudinal flex groove positioned just medial of the crash pads.