Determining whether there exists an input-output (I/O) fabric conflict (mismatch) between a blade I/O fabric daughter card of a blade compute module and an I/O interface module of a blade compute module system, and if a conflicts does exit then taking action to correct this I/O fabric mismatch. An I/O fabric router may be coupled between the blade I/O fabric daughter cards and the system I/O interface modules. If a matching I/O interface fabric exists then the I/O fabric router will couple the blade I/O fabric daughter card to the matching I/O interface fabric. If there is no matching I/O interface fabric then the blade I/O fabric daughter card may be decoupled from the blade compute module system so that the associated blade compute module may otherwise function, and an alert may be sent regarding the I/O fabric conflict (absence of an I/O fabric match) for the I/O fabric daughter card of the blade compute module.