The memory system includes a semiconductor memory that has an internal circuit, which operates according to a first power supply voltage, and a memory input/output circuit coupled to the internal circuit and operates according to a second power supply voltage, a first control unit that includes a control input/output circuit, coupled to the memory input/output circuit and operates according to the second power supply voltage, a voltage generating unit that generates the second power supply voltage and changes the second power supply voltage according to a voltage adjustment signal, a clock generating unit that generates the clock signal and changes the frequency of the clock signal according to a clock adjustment signal, and a second control unit that generates the voltage adjustment signal and the clock adjustment signal according to an access state of the semiconductor memory by the first control unit.