Invention Grant
US08148549B2 Preparation of (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl) propylamine using optically active methylhydroxylaminopropanol compound as an intermediate
有权
使用光学活性甲基羟基氨基丙醇化合物作为中间体制备（S） - （+） - N-甲基-3-（1-萘氧基）-3-（2-噻吩基）丙胺
- Patent Title: Preparation of (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl) propylamine using optically active methylhydroxylaminopropanol compound as an intermediate
- Patent Title (中): 使用光学活性甲基羟基氨基丙醇化合物作为中间体制备（S） - （+） - N-甲基-3-（1-萘氧基）-3-（2-噻吩基）丙胺
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Application No.: US12402740Application Date: 2009-03-12
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Publication No.: US08148549B2Publication Date: 2012-04-03
- Inventor: Bo-Fong Chen , Jinun-Ban Yeh , Wei-Chyun Wong
- Applicant: Bo-Fong Chen , Jinun-Ban Yeh , Wei-Chyun Wong
- Applicant Address: TW
- Assignee: SCI Pharmtech, Inc.
- Current Assignee: SCI Pharmtech, Inc.
- Current Assignee Address: TW
- Agency: Berliner & Associates
- Main IPC: C07D333/12
- IPC: C07D333/12 ; C07D333/20
Abstract:
The present invention provides a (S)-methylhydroxylaminopropanol derivative as an intermediate for preparation of (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine. The present invention also provides a process for preparing (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine with higher yield and lower cost, wherein the (S)-methylhydroxylaminopropanol derivative is used as an intermediate.
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