Invention Grant
US08148542B2 Method for producing crystal polymorphs of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid
有权
2-（3-氰基-4-异丁氧基苯基）-4-甲基-5-噻唑甲酸的晶体多晶型物的制备方法
- Patent Title: Method for producing crystal polymorphs of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid
- Patent Title (中): 2-（3-氰基-4-异丁氧基苯基）-4-甲基-5-噻唑甲酸的晶体多晶型物的制备方法
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Application No.: US12306170Application Date: 2007-06-22
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Publication No.: US08148542B2Publication Date: 2012-04-03
- Inventor: Mitsutaka Kitamura
- Applicant: Mitsutaka Kitamura
- Applicant Address: JP Tokyo
- Assignee: Teijin Pharma Limited
- Current Assignee: Teijin Pharma Limited
- Current Assignee Address: JP Tokyo
- Agency: Sughrue Mion, PLLC
- Priority: JP2006-173774 20060623
- International Application: PCT/JP2007/062593 WO 20070622
- International Announcement: WO2007/148787 WO 20071227
- Main IPC: C07D277/56
- IPC: C07D277/56
Abstract:
A method for producing crystal A of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid by dissolving 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid in methanol or a mixed solvent of methanol and water (the volume ratio of methanol to water is 90/10 or more), then adding water until the ratio of methanol to water becomes 7/3, and further adding a specific amount of a seed crystal at a specific timing during the addition of water.
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