Invention Grant
- Patent Title: Rhodanine derivatives, a process for the preparation thereof and pharmaceutical composition containing the same
- Patent Title (中): 罗丹宁衍生物，其制备方法和含有它们的药物组合物
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Application No.: US12087474Application Date: 2006-12-08
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Publication No.: US08148541B2Publication Date: 2012-04-03
- Inventor: Seong Eon Ryu , Seung Jun Kim , Dae Gwin Jeong , Sang Hyeup Lee , Suk Kyeong Jung , Hwan Mook Kim , Song Kyu Park , Ki Ho Lee , Chang Woo Lee , Joong-Kwon Choi , Jin Hee Ahn
- Applicant: Seong Eon Ryu , Seung Jun Kim , Dae Gwin Jeong , Sang Hyeup Lee , Suk Kyeong Jung , Hwan Mook Kim , Song Kyu Park , Ki Ho Lee , Chang Woo Lee , Joong-Kwon Choi , Jin Hee Ahn
- Applicant Address: KR Taejeon-Si
- Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee Address: KR Taejeon-Si
- Agency: The Nath Law Group
- Agent Tanya E. Harkins; Mihsuhn Koh
- Priority: KR10-2006-0002175 20060109
- International Application: PCT/KR2006/005343 WO 20061208
- International Announcement: WO2007/081091 WO 20070719
- Main IPC: C07D277/04
- IPC: C07D277/04 ; C07D417/02 ; C07D413/02 ; A61K31/535 ; A61K31/497 ; A61K31/425
Abstract:
Disclosed herein are rhodanine derivatives, a method for the preparation thereof, and a pharmaceutical composition containing the same. The rhodanine derivatives have inhibitory activity against protein phosphatases (PPase) such as PTP1B, Prl-3, LAR, CD45, Cdc25A, Cdc25B, Cdc25C, Yop, PP1 and VHR, and can be applied for the prevention and treatment of PPase-caused diseases, including autoimmune diseases, diabetes, impaired glucose intolerance, insulin resistance, obesity, cancers, etc. when the inhibitory activity thereof is modulated.
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