Invention Grant
- Patent Title: R-ALPHA1 antitrypsin anion exchange chromatography
- Patent Title (中): R-ALPHA1抗胰蛋白酶阴离子交换层析
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Application No.: US11693609Application Date: 2007-03-29
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Publication No.: US08148502B2Publication Date: 2012-04-03
- Inventor: Artur Mitterer , Meinhard Hasslacher , Christian Fiedler
- Applicant: Artur Mitterer , Meinhard Hasslacher , Christian Fiedler
- Applicant Address: US IL Deerfield CH Glattpark (Opfikon)
- Assignee: Baxter International Inc.,Baxter Healthcare S.A.
- Current Assignee: Baxter International Inc.,Baxter Healthcare S.A.
- Current Assignee Address: US IL Deerfield CH Glattpark (Opfikon)
- Agency: Morgan, Lewis & Bockius, LLP
- Main IPC: C07K1/00
- IPC: C07K1/00 ; C12Q1/00 ; C12P21/04
Abstract:
The present invention relates to a method for obtaining highly purified recombinant alpha1-antitrypsin (rAAT) using anion exchange chromatography, wherein a composition comprising rAAT and at least one impurity originating from cultivation of cells used for generating of rAAT is loaded onto a column containing anion exchange material and the anion exchange chromatography is carried out with buffers containing phosphate ions and N-acetylcysteine.
Public/Granted literature
- US20070260044A1 R-ALPHA1 ANTITRYPSIN ANION EXCHANGE CHROMATOGRAPHY Public/Granted day:2007-11-08
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