Invention Grant
- Patent Title: Phenylacetic acid derivative
- Patent Title (中): 苯乙酸衍生物
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Application No.: US12440540Application Date: 2007-09-10
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Publication No.: US08148421B2Publication Date: 2012-04-03
- Inventor: Hideo Kato , Osamu Nagata , Yoshiyuki Iwabuchi , Takahiro Sato , Junichiro Uda , Tutomu Inoue , Hiroshi Nakamura , Nobuhide Kawasaki , Ippei Tanaka , Naoki Kurita , Tomohiko Ishikawa
- Applicant: Hideo Kato , Osamu Nagata , Yoshiyuki Iwabuchi , Takahiro Sato , Junichiro Uda , Tutomu Inoue , Hiroshi Nakamura , Nobuhide Kawasaki , Ippei Tanaka , Naoki Kurita , Tomohiko Ishikawa
- Applicant Address: JP Saitama
- Assignee: Fuji Yakuhin Co., Ltd.
- Current Assignee: Fuji Yakuhin Co., Ltd.
- Current Assignee Address: JP Saitama
- Agency: Greenblum & Bernstein, PLC
- Priority: JP2006-245194 20060911
- International Application: PCT/JP2007/067568 WO 20070910
- International Announcement: WO2008/032665 WO 20080320
- Main IPC: A61K31/382
- IPC: A61K31/382 ; C07D335/02

Abstract:
A compound represented by the formula (1) or a salt thereof ( represents a single bond, or a double bond; R1 represents hydrogen atom, or an alkyl group; R2 and R3 represent hydrogen atom, or an alkyl group; R4 and R5 represent hydrogen atom, hydroxy group, an alkoxyl group, a halogen atom, or a mono- or di-alkyl-substituted amino group; R6 represents hydrogen atom, cyano group, an alkoxycarbonyl group, or carboxy group; R7 represents one or two of substituents on the benzene ring (the substituents are selected from hydrogen atom, a halogen atom, nitro group, cyano group, hydroxy group, amino group, an alkyl group, and an alkoxyl group); A represents a 5-membered or 6-membered non-aromatic heterocyclic ring containing one or two contiguous sulfur atoms (the sulfur atoms may independently form oxide); W represents oxo group, hydrogen atom, an alkyl group, hydroxy group, an alkoxyl group, or a halogen atom; and X represents oxygen atom, or sulfur atom), or a salt thereof, which has a superior suppressing action against prostaglandin E2 production and is useful as an active ingredient of medicaments with reduced adverse reactions such as gastrointestinal disorders.
Public/Granted literature
- US20100048666A1 NOVEL PHENYLACETIC ACID DERIVATIVE Public/Granted day:2010-02-25
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