Invention Grant
US08148354B2 Use of 20(S)-protopanaxadiol in manufacture of antidepressants
有权
使用20（S） - 原人参二醇制造抗抑郁药
- Patent Title: Use of 20(S)-protopanaxadiol in manufacture of antidepressants
- Patent Title (中): 使用20（S） - 原人参二醇制造抗抑郁药
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Application No.: US12304114Application Date: 2007-06-08
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Publication No.: US08148354B2Publication Date: 2012-04-03
- Inventor: Yongzheng Hui , Zirong Yang , Zhiqi Yang , Qiang Ge
- Applicant: Yongzheng Hui , Zirong Yang , Zhiqi Yang , Qiang Ge
- Applicant Address: CN Shanghai
- Assignee: Shanghai Innovative Research Center of Traditional Chinese Medicine
- Current Assignee: Shanghai Innovative Research Center of Traditional Chinese Medicine
- Current Assignee Address: CN Shanghai
- Agency: Perkins Coie LLP
- Agent Yingli Wang
- Priority: CN200610027507 20060609
- International Application: PCT/CN2007/001816 WO 20070608
- International Announcement: WO2007/143930 WO 20071221
- Main IPC: A61K31/56
- IPC: A61K31/56 ; C07J9/00
Abstract:
The invention provides the novel use of 20(S)-protopanaxadiol in the preparation of medicaments for the treatment of depressive psychiatric disorders. The pharmacological test results indicated that the compound could remarkably increase the level of NE, 5-HT and HAV in the brains of model rats having depressive disorders, remarkably enhance tremors induced by 5-hydroxytryptophan (5-HTP) and behavioral effects induced by levodopa, and inhibit the re-uptake of 5-HT and NA.
Public/Granted literature
- US20100234624A1 USE OF 20(S)-PROTOPANAXADIOL IN MANUFACTURE OF ANTIDEPRESSANTS Public/Granted day:2010-09-16
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