Invention Grant
- Patent Title: Bioconjugates as therapeutic agent and synthesis thereof
- Patent Title (中): 生物共轭物作为治疗剂及其合成
-
Application No.: US12234233Application Date: 2008-09-19
-
Publication No.: US08148321B2Publication Date: 2012-04-03
- Inventor: Rajendra Prasad Roy , Sharmishtha Samantaray
- Applicant: Rajendra Prasad Roy , Sharmishtha Samantaray
- Applicant Address: US IN New Dehli
- Assignee: National Institute of Immunology
- Current Assignee: National Institute of Immunology
- Current Assignee Address: US IN New Dehli
- Agency: Reinhart Boerner Van Deuren P.C.
- Priority: IN797/DEL/2006 20060322
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K31/70 ; A01N43/04
Abstract:
The present disclosure relates to a novel enzymatic approach according to the invention using an unprecedented sortase-catalyzed transpeptidation reaction between a substrate comprising LPXTG (SEQ ID NO: 11) peptide motif and biomolecules such as aminosugars, hydroxyamino acids, hydroxyamino acid esters, aminolipids, polyamines; nucleic acids or derivatives thereof; or any molecule having such moieties; or any compound having such moieties to obtain a bioconjugates useful for target delivery of a compound. The present disclosure provides bioconjugates obtained by the novel sortase catalysed transpeptidedation reaction.
Public/Granted literature
- US20090088372A1 Novel Bioconjugates As Therapeutic Agent and Synthesis Thereof Public/Granted day:2009-04-02
Information query
IPC分类:
