Invention Grant
US08148121B2 Δ6 desaturases and their use in making polyunsaturated fatty acids 有权
&Dgr; 6去饱和酶及其在制备多不饱和脂肪酸中的应用

Δ6 desaturases and their use in making polyunsaturated fatty acids
Abstract:
The present invention relates to Δ6 desaturases, which have the ability to convert linoleic acid [“LA”; 18:2 ω-6] to γ-linolenic acid [“GLA”; 18:3 ω-6] and/or α-linolenic acid [“ALA”; 18:3 ω-3] to stearidonic acid [“STA”; 18:4 ω-3]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ6 desaturases, along with methods of making long-chain polyunsaturated fatty acids [“PUFAs”] using these Δ6 desaturases in oleaginous yeast, are disclosed.
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