Invention Grant
- Patent Title: Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases
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Application No.: US13023128Application Date: 2011-02-08
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Publication No.: US08148106B2Publication Date: 2012-04-03
- Inventor: Sek Chung Fung , Kang Li , Yucheng Li , Sanjaya Singh , Bin-Bing Stephen Zhou
- Applicant: Sek Chung Fung , Kang Li , Yucheng Li , Sanjaya Singh , Bin-Bing Stephen Zhou
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Genentech, Inc.
- Agent Danielle Pasqualone; Julia vom Wege
- Main IPC: C12P21/06
- IPC: C12P21/06
Abstract:
The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
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