Invention Grant
- Patent Title: Anti-CD19 antibodies
- Patent Title (中): 抗CD19抗体
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Application No.: US12907262Application Date: 2010-10-19
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Publication No.: US08147831B2Publication Date: 2012-04-03
- Inventor: Hans J. Hansen , Zhengxing Qu , David M. Goldenberg
- Applicant: Hans J. Hansen , Zhengxing Qu , David M. Goldenberg
- Applicant Address: US NJ Morris Plains
- Assignee: Immunomedics, Inc.
- Current Assignee: Immunomedics, Inc.
- Current Assignee Address: US NJ Morris Plains
- Agent Richard A. Nakashima
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K39/40 ; C07K16/00

Abstract:
The present invention provides humanized, chimeric and human anti-CD19 antibodies, anti-CD19 antibody fusion proteins, and fragments thereof that bind to a human B cell marker. Such antibodies, fusion proteins and fragments thereof are useful for the treatment and diagnosis of various B-cell disorders, including B-cell malignancies and autoimmune diseases. In more particular embodiments, the humanized anti-CD19 antibodies may comprise one or more framework region amino acid substitutions designed to improve protein stability, antibody binding and/or expression levels. In a particularly preferred embodiment, the substitutions comprise a Ser91Phe substitution in the hA19 VH sequence.
Public/Granted literature
- US20110052489A1 Anti-CD19 Antibodies Public/Granted day:2011-03-03
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