Invention Grant
- Patent Title: Methods and compositions for modulation of blood-neural barrier
- Patent Title (中): 调节血液神经屏障的方法和组成
-
Application No.: US11736499Application Date: 2007-04-17
-
Publication No.: US08147828B2Publication Date: 2012-04-03
- Inventor: Ulf Eriksson , Daniel Lawrence , Enming Joe Su , Dudley Strickland , Manuel Yepes , Linda Fredriksson
- Applicant: Ulf Eriksson , Daniel Lawrence , Enming Joe Su , Dudley Strickland , Manuel Yepes , Linda Fredriksson
- Applicant Address: US NY New York US MD Baltimore US MI Ann Arbor
- Assignee: Ludwig Institute for Cancer Research,University of Maryland,The Regents of the University of Michigan
- Current Assignee: Ludwig Institute for Cancer Research,University of Maryland,The Regents of the University of Michigan
- Current Assignee Address: US NY New York US MD Baltimore US MI Ann Arbor
- Agency: Fox Rothschild LLP
- Agent Janet M. MacLeod
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; C07K14/71
Abstract:
Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-α antagonist.
Public/Granted literature
- US20070265203A1 METHODS AND COMPOSITIONS FOR MODULATION OF BLOOD-NEURAL BARRIER Public/Granted day:2007-11-15
Information query
