A brake system for a motorcycle includes a pressure-regulating unit interposed between a fluid pressure-generating unit and a wheel brake. Operation of a pressure-regulating unit is managed and controlled by a control unit, based primarily on an applied force detected by an operating amount detector. The fluid pressure-generating unit is disposed between an engine body, mounted on a body frame, and an exhaust pipe which is connected to a front surface of a cylinder head of the engine body, and which extends downwardly from the cylinder head. The fluid pressure-generating unit is arranged on the body frame such that, during operation of the motorcycle, the fluid pressure-generating unit is substantially shielded and isolated from heat emitted by the engine body and the exhaust pipe.