An apparatus and method for interference cancellation in a multi-antenna system are provided. A transmission apparatus includes a channel identifier, a scheduler, an interference canceller, and a transmitter. The channel identifier identifies channel information of each of a plurality of receiving ends located in a service area and neighbor cell interference information on each receiving end. The scheduler selects at least one receiving end. The interference canceller precodes transmitted signals in order to cancel interference between receiving ends located in the same cell and neighbor cell interference. The transmitter transmits the precoded transmitted signals to the selected at least one receiving end.