A data processing system includes an interconnect fabric, a system memory coupled to the interconnect fabric and including a virtual barrier synchronization region allocated to storage of virtual barrier synchronization registers (VBSRs), and a plurality of processing units coupled to the interconnect fabric and operable to access the virtual barrier synchronization region of the system memory. Each of the plurality of processing units includes a processor core and a cache memory including a cache array that caches VBSR lines from the virtual barrier synchronization region of the system memory and a cache controller. The cache controller, responsive to a store request from the processor core to update a particular VBSR line, performs a non-blocking update of the cache array in each other of the plurality of processing units contemporaneously holding a copy of the particular VBSR line by transmitting a VBSR update command on the interconnect fabric.