Methods and systems for a software defined power amplifier for multi-band, multi-standard applications are disclosed and may comprise configuring a single programmable output stage of a multi-band, multi-standard transmitter to handle transmission of a signal according to multiple wireless communication protocols and frequency ranges. The output stage may be configured by coupling a power amplifier (PA) within the programmable output stage to a switch or a duplexer, which may be coupled to one or more of multiple antennas, each of which may handle signals in a different frequency range. Each antenna may be impedance matched with the power amplifier using transformers, and may be coupled by activating at least one integrated transistor. The PA may be biased to operate in one of a plurality of classes of operation comprising Class A, AB, C and F associated with the wireless communication protocols, which may comprise EDGE, GSM, WCDMA and wireless LAN.