Invention Grant
US08129515B2 Oligomeric compounds and compositions for the use in modulation of microRNAs
有权
用于调节微小RNA的低聚化合物和组合物
- Patent Title: Oligomeric compounds and compositions for the use in modulation of microRNAs
- Patent Title (中): 用于调节微小RNA的低聚化合物和组合物
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Application No.: US12161286Application Date: 2007-01-27
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Publication No.: US08129515B2Publication Date: 2012-03-06
- Inventor: Christine Esau , Eric E. Swayze , Balkrishen Bhat , Garth A. Kinberger
- Applicant: Christine Esau , Eric E. Swayze , Balkrishen Bhat , Garth A. Kinberger
- Applicant Address: US CA Carlsbad
- Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: Isis Pharmaceuticals, Inc. Patent Department
- International Application: PCT/US2007/061186 WO 20070127
- International Announcement: WO2007/090073 WO 20070809
- Main IPC: C07H21/04
- IPC: C07H21/04 ; A61K31/70
Abstract:
Compounds, compositions and methods are provided for modulating the levels expression, processing and function of miRNAs. The compositions comprise oligomeric compounds targeted to small non-coding RNAs and miRNAs. The oligomeric compounds possess potent miRNA inhibitory activity, and further exhibit improved therapeutic index. Further provided are methods for selectively modulating miRNA activity in a cell.
Public/Granted literature
- US20090221685A1 OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR THE USE IN MODULATION OF MICRORNAS Public/Granted day:2009-09-03
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