Invention Grant
US08129421B2 Method for preparing 4-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]-benzoic acid
有权
4- [3,5-双（2-羟基苯基） - [1,2,4]三唑-1-基] - 苯甲酸的制备方法
![Method for preparing 4-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]-benzoic acid](/docs/US/2012-03-06/US08129421B2/abs.jpg.600x600.jpg)
- Patent Title: Method for preparing 4-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]-benzoic acid
- Patent Title (中): 4- [3,5-双（2-羟基苯基） - [1,2,4]三唑-1-基] - 苯甲酸的制备方法
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Application No.: US12864907Application Date: 2008-06-16
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Publication No.: US08129421B2Publication Date: 2012-03-06
- Inventor: Radek Melnicky , Pavel Hradil , Lubomir Kvapil , Martin Grepl , Petr Slezar
- Applicant: Radek Melnicky , Pavel Hradil , Lubomir Kvapil , Martin Grepl , Petr Slezar
- Applicant Address: CZ Olomouc
- Assignee: Farmak, A S
- Current Assignee: Farmak, A S
- Current Assignee Address: CZ Olomouc
- Agency: Pearl Cohen Zedek Latzer, LLP
- Priority: CZPV2008-49 20080130
- International Application: PCT/CZ2008/000068 WO 20080616
- International Announcement: WO2009/094956 WO 20090806
- Main IPC: A61K31/41
- IPC: A61K31/41 ; C07D249/08
![Method for preparing 4-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]-benzoic acid](/abs-image/US/2012/03/06/US08129421B2/abs.jpg.150x150.jpg)
Abstract:
A method for preparing 4-[3,5-bis(2-hydroxyphenyl )-[1,2,4]triazol-1-yl]benzoic acid of formula (I) by reaction of 2-(2-hydroxyphenyl)benz[e][1,3]oxazin-4-one of formula (II) with 4-hydrazinobenzoic acid of formula (III) in an organic acid or in a mixture of an organic acid and an organic solvent.
Public/Granted literature
- US20110034702A1 METHOD FOR PREPARING 4-[3,5-BIS(2-HYDROXYPHENYL)-[1,2,4]TRIAZOL-1-YL]-BENZOIC ACID Public/Granted day:2011-02-10
Information query
