Invention Grant
US08129187B2 Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
有权
通过编码Oct3 / 4的逆转录病毒载体进行体细胞重编程。 Klf4，c-Myc和Sox2
- Patent Title: Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
- Patent Title (中): 通过编码Oct3 / 4的逆转录病毒载体进行体细胞重编程。 Klf4，c-Myc和Sox2
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Application No.: US12656907Application Date: 2010-02-18
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Publication No.: US08129187B2Publication Date: 2012-03-06
- Inventor: Shinya Yamanaka , Kazutoshi Takahashi , Keisuke Okita
- Applicant: Shinya Yamanaka , Kazutoshi Takahashi , Keisuke Okita
- Applicant Address: JP Kyoto
- Assignee: Kyoto University
- Current Assignee: Kyoto University
- Current Assignee Address: JP Kyoto
- Agency: Knobbe Martens Olson & Bear LLP
- Priority: JP2005-359537 20051213
- Main IPC: C12N5/02
- IPC: C12N5/02 ; C12N15/00
Abstract:
The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generating and maintaining iPS cells, and methods of using iPS cells, including screening and testing methods as well as methods of stem cell therapy. The present invention also relates to somatic cells derived by inducing differentiation of the aforementioned iPS cells.
Public/Granted literature
- US20100216236A1 Nuclear reprogramming factor and induced pluripotent stem cells Public/Granted day:2010-08-26
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