Invention Grant
US08129173B2 Selective enzymatic esterification and solvolysis of epimeric vitamin D analog and separation of the epimers
失效
分解维生素D类似物的选择性酶酯化和溶剂解分解和差向异构体的分离
- Patent Title: Selective enzymatic esterification and solvolysis of epimeric vitamin D analog and separation of the epimers
- Patent Title (中): 分解维生素D类似物的选择性酶酯化和溶剂解分解和差向异构体的分离
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Application No.: US10339226Application Date: 2003-01-09
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Publication No.: US08129173B2Publication Date: 2012-03-06
- Inventor: Evgeny Shapiro , Ayelet Fishman , Reinhard Effenberger , Asher Maymon , Anchel Schwartz
- Applicant: Evgeny Shapiro , Ayelet Fishman , Reinhard Effenberger , Asher Maymon , Anchel Schwartz
- Applicant Address: IL Petah Tiqva
- Assignee: Teva Pharmaceutical Industries Ltd.
- Current Assignee: Teva Pharmaceutical Industries Ltd.
- Current Assignee Address: IL Petah Tiqva
- Agency: Kenyon & Kenyon LLP
- Main IPC: C12P7/02
- IPC: C12P7/02
Abstract:
Provided is a method of selectively enzymatically esterifying or selectively enzymatically solvolyzing epimers of analogs of vitamin D having a stereogenic center at C-24 that has a free or esterified OH group. The metod can be used, for example, for separating mixed epimers of the vitamin D analog.
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