Invention Grant
US08129146B2 Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
有权
制备酵母中发酵产量提高的胰岛素前体和胰岛素前体类似物的方法
- Patent Title: Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
- Patent Title (中): 制备酵母中发酵产量提高的胰岛素前体和胰岛素前体类似物的方法
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Application No.: US12104809Application Date: 2008-04-17
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Publication No.: US08129146B2Publication Date: 2012-03-06
- Inventor: Thomas Borglum Kjeldsen , Svend Ludvigsen
- Applicant: Thomas Borglum Kjeldsen , Svend Ludvigsen
- Applicant Address: DK Bagsvaerd
- Assignee: Novo Nordisk A/S
- Current Assignee: Novo Nordisk A/S
- Current Assignee Address: DK Bagsvaerd
- Agent Michael J. Brignati
- Priority: DK199901869 19991229; DK200000443 20000317
- Main IPC: C12N15/17
- IPC: C12N15/17
Abstract:
Novel insulin precursors and insulin precursor analogs comprising a connecting peptide (mini C-peptide) of preferably up to 15 amino acid residues and comprising at least one Gly are provided. The precursors can be converted into human insulin or a human insulin analog. The precursors will typically have a distance between B27 (atom CG2) and A1 (atom CA) of less than 5 Å.
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