Invention Grant
US08129137B2 Two-photon probe for real-time monitoring of intracellular free zinc ions, method for preparing the probe and method for real-time monitoring of intracellular free zinc ions using the probe
有权
用于实时监测细胞内游离锌离子的双光子探针，制备探针的方法和使用探针实时监测细胞内游离锌离子的方法
- Patent Title: Two-photon probe for real-time monitoring of intracellular free zinc ions, method for preparing the probe and method for real-time monitoring of intracellular free zinc ions using the probe
- Patent Title (中): 用于实时监测细胞内游离锌离子的双光子探针，制备探针的方法和使用探针实时监测细胞内游离锌离子的方法
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Application No.: US12454169Application Date: 2009-05-12
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Publication No.: US08129137B2Publication Date: 2012-03-06
- Inventor: Bong-Rae Cho
- Applicant: Bong-Rae Cho
- Applicant Address: KR Seoul
- Assignee: Korea University Industrial & Academic Collaboration Foundation
- Current Assignee: Korea University Industrial & Academic Collaboration Foundation
- Current Assignee Address: KR Seoul
- Agency: Christie, Parker & Hale, LLP
- Priority: KR10-2008-0044176 20080513
- Main IPC: C12Q1/02
- IPC: C12Q1/02 ; C07D213/00
Abstract:
A two-photon probe for real-time monitoring of intracellular free zinc ions is provided. The two-photon probe is represented by Formula 1: wherein R is H or OCH3. The two-photon probe has high selectivity for Zn2+ and enables very effective and long-term monitoring of intracellular free Zn2+ present in the deep tissue. Further provided are a method for preparing the two-photon probe and a method for real-time monitoring of intracellular free zinc ions using the two-photon probe.
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