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US08128803B2 Method and system for determining the concentration of an analyte/enzyme complex or of an analyte/enzyme conjugate, especially for the electrochemical detection of the analyte, and corresponding measuring device 有权
用于确定分析物/酶复合物或分析物/酶缀合物的浓度的方法和系统，特别是用于分析物的电化学检测，以及对应的测量装置

  • Patent Title: Method and system for determining the concentration of an analyte/enzyme complex or of an analyte/enzyme conjugate, especially for the electrochemical detection of the analyte, and corresponding measuring device
  • Patent Title (中): 用于确定分析物/酶复合物或分析物/酶缀合物的浓度的方法和系统，特别是用于分析物的电化学检测，以及对应的测量装置
  • Application No.: US11989938
    Application Date: 2006-07-31
  • Publication No.: US08128803B2
    Publication Date: 2012-03-06
  • Inventor: Heike Barlag , Walter Gumbrecht , Konrad Mund
  • Applicant: Heike Barlag , Walter Gumbrecht , Konrad Mund
  • Applicant Address: DE Munich
  • Assignee: Siemens Aktiengesellschaft
  • Current Assignee: Siemens Aktiengesellschaft
  • Current Assignee Address: DE Munich
  • Agency: Staas & Halsey LLP
  • Priority: DE102005037436 20050804
  • International Application: PCT/EP2006/064842 WO 20060731
  • International Announcement: WO2007/014931 WO 20070208
  • Main IPC: G01N33/543
  • IPC: G01N33/543 ;  G01N27/26 ;  G01N27/49
Method and system for determining the concentration of an analyte/enzyme complex or of an analyte/enzyme conjugate, especially for the electrochemical detection of the analyte, and corresponding measuring device
Abstract:
A method follow the change in concentration of a redox-active substance, whereby suitable potentials for a reduction process or an oxidation process are applied to the working electrode of a measuring device. The potential of the working electrode is pulsed and measuring phases and relaxation phases are alternately produced, the pulse lengths of measuring phase and relaxation phase being determined in a suitable manner. A rapid relaxation of the concentration gradient is electrochemically forced so that the measurement can be carried out on simple transducer arrays. A device for carrying out the method includes a transducer array in addition to a suitable potentiostat. The transducer array can be formed of a planar metal substrate on which at least one flexible insulator is disposed, the metal surface and the insulator surface being firmly linked. The transducer array can also be formed of silicone-based CMOS structures.
Abstract(Chinese):

一种遵循氧化还原活性物质浓度变化的方法，由此将适当的还原过程或氧化过程的电位施加到测量装置的工作电极上。 工作电极的电位是脉冲的，并且交替地产生测量相位和松弛相位，测量相位和弛豫阶段的脉冲长度以适当的方式确定。 浓度梯度的快速弛豫是电化学强制的，以便可以在简单的换能器阵列上进行测量。 用于执行该方法的装置包括除合适的恒电位仪之外的换能器阵列。 换能器阵列可以由其上设置有至少一个柔性绝缘体的平面金属基板形成，金属表面和绝缘体表面牢固地连接。 换能器阵列也可以由硅基CMOS结构形成。

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