Provided are a multiple antenna receiver and a method of receiving a signal. A multiple antenna receiver includes a plurality of antennas to receive a plurality of received symbols, a QR decomposition unit to perform QR decomposition for a channel matrix, a Q-received symbol generator to generate Q-received symbols corresponding to the plurality of antennas, a subtractor to remove a component corresponding to at least one neighbor symbol from a target received symbol corresponding to one of the Q-received symbols, an adder to add a signal component to the target received symbol, a first FDE to perform frequency domain equalization for an output of the subtractor, and a second FDE to perform frequency domain equalization for an output of the adder.