Invention Grant
US08093395B2 Sphingosine compound, method for producing the same, and sphingomyelinase inhibitor
失效
鞘氨醇化合物，其制造方法和鞘磷脂酶抑制剂
- Patent Title: Sphingosine compound, method for producing the same, and sphingomyelinase inhibitor
- Patent Title (中): 鞘氨醇化合物，其制造方法和鞘磷脂酶抑制剂
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Application No.: US12530311Application Date: 2008-03-05
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Publication No.: US08093395B2Publication Date: 2012-01-10
- Inventor: Mugio Nishizawa , Hiroshi Imagawa , Jun Sakurai , Masataka Oda
- Applicant: Mugio Nishizawa , Hiroshi Imagawa , Jun Sakurai , Masataka Oda
- Applicant Address: JP Osaka-Shi
- Assignee: Otsuka Chemical Co., Ltd.
- Current Assignee: Otsuka Chemical Co., Ltd.
- Current Assignee Address: JP Osaka-Shi
- Agency: Kratz, Quintos & Hanson, LLP
- Priority: JP2007-60950 20070309
- International Application: PCT/JP2008/053936 WO 20080305
- International Announcement: WO2008/111450 WO 20080918
- Main IPC: C07D211/70
- IPC: C07D211/70 ; A61K31/44
Abstract:
An object of the invention is to provide a novel sphingosine compound with an inhibitory activity against sphingomyelinase, and a method for producing the sphingosine compound.The novel sphingosine compound or a salt thereof according to the invention is represented by Formula (1): wherein one of R1 and R2 is hydrogen, and the other is a group represented by Formula (G): wherein n is 0 or 1; and R3 is hydrogen, C1-23 alkyl, C3-8 cycloalkyl, C2-6 alkenyl, C1-6 alkoxy, C3-8 cycloalkyloxy, phenyl, or furil.
Public/Granted literature
- US20100099881A1 SPHINGOSINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND SPHINGOMYELINASE INHIBITOR Public/Granted day:2010-04-22
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