Invention Grant
US08093393B2 Cationic ceramides, and analogs thereof, and their use for preventing or treating cancer
有权
阳离子神经酰胺及其类似物及其用于预防或治疗癌症的用途
- Patent Title: Cationic ceramides, and analogs thereof, and their use for preventing or treating cancer
- Patent Title (中): 阳离子神经酰胺及其类似物及其用于预防或治疗癌症的用途
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Application No.: US11666518Application Date: 2005-10-31
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Publication No.: US08093393B2Publication Date: 2012-01-10
- Inventor: Alicja Bielawska , Zdzislaw M. Szulc , Yusuf A. Hannun , Lina M. Obeid , Besim Ogretmen
- Applicant: Alicja Bielawska , Zdzislaw M. Szulc , Yusuf A. Hannun , Lina M. Obeid , Besim Ogretmen
- Applicant Address: US SC Charleston
- Assignee: MUSC Foundation for Research Development
- Current Assignee: MUSC Foundation for Research Development
- Current Assignee Address: US SC Charleston
- Agency: Jenkins, Wilson, Taylor & Hunt, P.A.
- International Application: PCT/US2005/039271 WO 20051031
- International Announcement: WO2006/050264 WO 20060511
- Main IPC: C07D211/00
- IPC: C07D211/00 ; C07D211/92
Abstract:
The present invention relates to cationic ceramides, their dihydro-analogs and aromatic analogs and their derivatives, comprising a pyridinium group. Also provided are methods for making cationic ceramides comprising a pyridinium group, and their use for treating or preventing diseases associated with cell overproliferation and sphingolipid signal transduction, such as cancer, inflammation, and stenosis. The compounds are also useful as mitochondritropic agents that are localized to mitochondria carrying with them chemical cargoes, such as drugs, or signaling molecules, such as fluorophores for probing organelle structure and functions.
Public/Granted literature
- US20110071099A1 Cationic Ceramides, And Analogs Thereof, And Their Use For Preventing Or Treating Cancer Public/Granted day:2011-03-24
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