A multiplier-accumulator includes a pre-adder, a multiplier, an accumulator, multiplexing logic, and control logic. The pre-adder is configured to sum a first input and a second input to produce a pre-sum output. The multiplier is configured to multiply a third input and the pre-sum output to produce a product output. The accumulator is configured to sum a pair of accumulator inputs to produce a sum output. The multiplexer is configured to select the pair of accumulator inputs from a plurality of multiplexer inputs, where the plurality of multiplexer inputs includes the product output and the sum output. The control logic is configured to control operation of the pre-adder, the accumulator, and the multiplexer logic. In an example, each of the first input, the second input, the third input, and the sum output is coupled to programmable interconnect of a programmable logic device.